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Komáromy, D.; Monzón, D. M.; Marić, I.; Monreal Santiago, G.; Ottelé, J.; Altay, M.; Schaeffer, G.; Otto, S. Generalist versus Specialist Self-Replicators. Chem. Eur. J. 2024 e202303837


Maric, I.; Yang, L.; Li, X.; Monreal Santiago, G.; Pappas, C.; Qiu, X.; Dijksman, J. A.; Mikhailov, K.; van Rijn, P.; Otto, S. Tailorable and Biocompatible Supramolecular-Based Hydrogels Featuring two Dynamic Covalent Chemistries. Angew. Chem. Int. Ed. 2023, e202216475

Sun, J.; *Monreal Santiago, G.; Yan, F.; Zhou, W. Rudolf, P.; Portale, G.; *Kamperman, M. Bioinspired Processing of Keratin into Upcycled Fibers through pH- Induced Coacervation. ACS Sustainable Chem. Eng. 2023, 11, 1985−1994

* = Corresponding author


Bartolec, B.;  Kiani, A.; Beatty, M. A.; Altay, M.; Monreal Santiago, G.Otto, S. Selection of diverse polymorphic structures from a small dynamic molecular network controlled by the environment. Chem. Sci. 2022, 13, 14300-14304.

Sun, J; *Monreal Santiago, G.; Zhou, W.; Portale, G.; *Kamperman, M. Water-Processable, Stretchable, and Ion-Conducting Coacervate Fibers from Keratin Associations with Polyelectrolytes. ACS Sustainable Chem. Eng. 2022, 10, 48, 15968–15977. 

* = Corresponding author

+Matysiak, B. M.; +Monreal Santiago, G.; Otto, S. Teaching an Old Compound New Tricks: Reversible Transamidation in Maleamic Acids. Chem. Eur. J. 2022, 28 (40), e202201043. 

+ = Equal contribution


Komáromy, D.; Tiemersma-Wegman, T.; Kemmink, J.; Portale, G.; Adamski, P. R.; Blokhuis, A.; Aalbers, F. S.; Marić, I.; Monreal Santiago, G.; Ottelé, J.; Sood, A.; Saggiomo, V.; Liu, B.; van der Meulen, P.; Otto, S. Stoichiometry Alone Can Steer Supramolecular Systems on Complex Free Energy Surfaces with High Selectivity. Chem 2021, 7 (7), 1933–1951. 


Maity, S.; Ottelé, J.; Monreal Santiago, G.; Frederix, P. W. J. M.; Kroon, P.; Markovitch, O.; Stuart, M. C. A.; Marrink, S. J.; Otto, S.; Roos, W. H. Caught in the Act: Mechanistic Insight into Supramolecular Polymerization-Driven Self-Replication from Real-Time Visualization. J. Am. Chem. Soc. 2020, 142 (32), 13709–13717. 

Monreal Santiago, G.; Liu, K.; Browne, W. R.; Otto, S. Emergence of Light-Driven Protometabolism on Recruitment of a Photocatalytic Cofactor by a Self-Replicator. Nat. Chem. 2020, 12 (7), 603–607. 

ChemRxiv link

Behind the paper in Nature Chemistry Community

News and Views article in Nature Chemistry

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Cvrtila, I.; Fanlo-Virgós, H.; Monreal Santiago, G.; Otto, S.  Accelerating Hydrazone Exchange by UV Irradiation J. Sys. Chem. 2020, 8, 73-81. Link


Bartolec, B.; Leonetti, G.; Li, J.; Smit, W.; Altay, M.; Monreal Santiago, G.; Yan, Y.; Otto, S. Emergence of Compartments Formed from Unconventional Surfactants in Dynamic Combinatorial Libraries. Langmuir 2019, 35 (17), 5787–5792.

Malakoutikhah, M.; Schaeffer, G.; Monreal Santiago, G.; Yang, S.; Marić, I.; Otto, S. Cross-Catalysis between Self-Replicators of Different Handedness. J. Sys. Chem. 2019, 7, 9-18. Link to Abstract


Cvrtila, I.; Fanlo-Virgós, H.; Schaeffer, G.; Monreal Santiago, G.; Otto, S. Redox Control over Acyl Hydrazone Photoswitches. J. Am. Chem. Soc. 2017, 139 (36), 12459–12465. 


Hertzberg, R.; Monreal Santiago, G.; Moberg, C. Synthesis of the Β3-Adrenergic Receptor Agonist Solabegron and Analogous N-(2-Ethylamino)-β-Amino Alcohols from O-Acylated Cyanohydrins – Expanding the Scope of Minor Enantiomer Recycling. J. Org. Chem. 2015, 80 (5), 2937–2941.